Rajaraman Krishnan,Eva Asp,Ming Proschitsky,Richard Fisher,Francis J. Carr,Robert G.E. Holgate,Timothy D. Jones
申请号：
US15532820
公开号：
US20180207231A1
申请日:
2015.12.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid deletion, insertion or substitution to remove a putative glycosylation signal. The invention further relates to such polypeptides that are also modified through additional amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability to bind and/or disaggregate amyloid. The invention further relates to the use of these g3p-modified polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
