KRISHNAN RAJARAMAN,ASP EVA,PROSCHITSKY MING,FISHER RICHARD,CARR FRANCIS J,HOLGATE ROBERT G E,JONES TIMOTHY D
申请号：
IN201717018432
公开号：
IN201717018432A
申请日:
2017.05.25
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid e.g. the N1 N2 portion of g3p and mutants and fragments thereof wherein that g3p amino acid sequence has been modified through amino acid deletion insertion or substitution to remove a putative glycosylation signal. The invention further relates to such polypeptides that are also modified through additional amino acid substitution to be substantially less immunogenic than the corresponding wild type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability to bind and/or disaggregate amyloid. The invention further relates to the use of these g3p modified polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
