The invention discloses a kind of one individuals for the treatment of by the method for the symptom of mycobacterium tuberculosis infection comprising bestows compound shown in the Formulas I of a pharmaceutical effective dose to the individual. In the preferred embodiment, series of compounds shown in Formulas I is (3R, 4S) -1- (4- fluorophenyl) -3- [(3S) -3- (4- fluorophenyl) -3- hydroxypropyl] -4- (4- hydroxyphenyl) azetidine -2- ketone, inhibit Intracellular survival and growth of the mycobacterium tuberculosis in monocyte with can dramatically, treating tuberculosis effect system causes monocyte activation thereby to kill mycobacterium tuberculosis Wei CD13 is partly transmitted.本發明揭露一種治療一個體受結核分枝桿菌感染之症狀的方法，其包括對該個體施予一藥學上有效劑量之式I所示之化合物。在較佳實施例中，式I所示之化合物係為(3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羥丙基]-4-(4-羥苯基)氮雜環丁烷-2-酮，可顯著地抑制結核分枝桿菌在單核細胞中的胞內存活及生長，其抗結核效果係為部分地透過CD13而導致單核細胞活化以藉此殺死結核分枝桿菌。
