Silicone adhesive dressings that are antimicrobial and can include a backing layer are for use on wound areas and surgical incisions and as a protective dressing to cover, for example, indwelling therapeutic devices. The dressings include polyhexamethylene biguanide (PHMB) and ethylenediamine tetraacetic acid (EDTA) in a silicone layer as particulates, and optionally include glycerin.
