597621 Disclosed is the use of a flowable composition comprising: (i) a biodegradable thermoplastic polymer that is a polyester of one or more hydroxycarboxylic acids, or is a polyester of a combination of one or more diols and one or more dicarboxylic acids； (ii) a biocompatible polar aprotic organic liquid selected from the group consisting of an amide, an ester, a carbonate, a ketone, an ether, a sulfonyl, and any combination thereof； and (iii) an effective amount of risperidone, 9-hydroxyrisperidone or a pharmaceutically acceptable organic or inorganic salt thereof； in the manufacture of a medicament for the treatment of medical condition selected from the group consisting of delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive compulsion disorder, Tourette syndrome, autistic spectrum disorders, and any combination thereof； wherein the medicament is adapted to be injected into a patient and further wherein the medicament is formulated to form a solid microporous biodegradable implant under physiological conditions； and wherein the implant releases the effective amount of the risperidone, 9-hydroxyrisperidone or pharmaceutically acceptable organic or inorganic salt thereof by diffusion, erosion, or a combination of diffusion and erosion as the implant biodegrades in the patient.
