Федеральное государственное автономное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ)
发明人:
Соколов Павел Михайлович (RU),Набиев Игорь Руфаилович (RU),Нифонтова Галина Олеговна (RU)
申请号：
RU2019129881
公开号：
RU0000196226U1
申请日:
2019.09.24
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
The utility model relates to the field of medical research and cancer therapy. A carrier for the targeted delivery and controlled release of drugs is disclosed, which is a microcapsule, the shell of which consists of layers of polyelectrolytes, and single-domain antibodies specific to cancer markers are immobilized on the surface of the outer layer of the polyelectrolyte between the layers of polyelectrolytes a layer is applied, including magnetic nanoparticles, a layer, including infrared e quantum dots, as well as a layer including plasmon nanoparticles, where the layers of infrared quantum dots, magnetic and plasmon nanoparticles are separated by three alternating layers of polyelectrolytes of different charges, while the shell itself is made with the possibility of destruction in response to radiation, and there is a drug inside the microcapsule. At the same time, the molecules of the organic fluorescent dye are located on the surface of the microcapsule, which are connected to the surface of the microcapsule using a linker, which ensures the convergence of the organic fluorescent dye and quantum dots when the pH changes from neutral to weakly acid, while the organic fluorescent dye and quantum dots are selected so that the fluorescence spectrum of quantum dots makes it possible to excite fluorescence of an organic fluorescent dye. The technical result of the proposed A useful model is to reduce the cost of manufacturing and using the carrier for diagnostics, targeted delivery and controlled release of drugs, as well as increasing the usability, due to the possibility of detecting the penetration and accumulation of the carrier inside the tumor using only optical methods. 10 s.p. f-ly, 1 ill.Полезная модель относится к области медицинских исследований и терапии онкологических заболеваний.Раскрыт носитель для направленной доставки и контролируемого высвобождения лекарственных средств, представляющий собой микрокапсулу, оболочка которой состоит из слоев полиэлектр
