Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride is described. Compositions incorporating such materials, as well as methods of preparing such materials are also described.L'invention concerne un gluconate de chlorhexidine solubilisé dans un monoacylglycéride hydrophobe. L'invention concerne également des compositions comprenant de telles matières, ainsi que des procédés de préparation de telles matières.