The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.本發明係關於一種適用於合成醫藥上活性化合物,特定言之中性肽鏈內切酶(NEP)抑制劑及其前藥之新穎方法、新穎方法步驟及新穎中間物。