The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention methods of treating of various diseases, disorders, and conditions using the compounds of this invention processes for preparing the compounds of this invention intermediates for the preparation of the compounds of this invention and solid forms of the compounds of this invention.The compounds of this invention have formula I or II: wherein the variables are as defined herein.本發明係關於用於製備適用作ATR激酶抑制劑之化合物之方法及中間物,該等化合物諸如為胺基吡嗪-異噁唑衍生物及相關分子。本發明亦關於適用作ATR蛋白激酶抑制劑之化合物。本發明係關於包含本發明化合物之醫藥學上可接受之組合物;使用本發明化合物治療各種疾病、病症及病況之方法;製備本發明化合物之方法;用於製備本發明化合物之中間物;及本發明化合物之固體形式。本發明化合物具有式I或式II:其中各變數如本文中所定義。
