Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
Hilgraf Robert,Yong Kelvin Hin-Yeong,Muslehiddinoglu Jale,Kothare Mohit Atul,Zou Nanfei,Li Ying,Boersen Nathan Andrew,Huang Lianfeng,Beauchamps Marie Georges,Man Hon-Wah,Ferretti Antonio Christian,Xu
申请号：
NZ71590314
公开号：
NZ715903A
申请日:
2014.09.03
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Provided are crystalline and amorphous forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide (formula 1). Further provided are intermediates useful in the preparation of the compounds. The compounds are JNK 1 and JNK2 inhibitors. The compounds may be useful in the treatment or prevention of interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, lupus, liver fibrotic disorders, diabetes or metabolic syndromes leading to liver fibrotic disorders.
