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IBUPROFEN AND NARCOTIC ANALGESIC COMPOSITIONS
专利权人:
AbbVie Deutschland GmbH & Co. KG
发明人:
Gregory P. Kushla,Jin-Wang Lai,Gerald P. Polli
申请号:
US13708291
公开号:
US20130165518A1
申请日:
2012.12.07
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising ibuprofen a narcotic analgesic colloidal silicon dioxide a filler selected from the group consisting of microcrystalline cellulose and powdered cellulose a disintegrant selected from the group consisting of croscarmellose sodium, crospovidone, and sodium starch glycolate a binder consisting of an akylhydroxy methylcellulose a starch and a lubricant. Also provided herein is a method of preparing a pharmaceutical tablet composition comprising: (a) Granulating ibuprofen, a narcotic analgesic, a first glidant, a first disintegrant, a binder, and starch to form granules wherein said granulating step comprises a wet granulation process (b) blending the granules with extra-granular material comprised of a second glidant, a second disintegrant, a filler and starch to form a blend of granules and extra-granular material and (c) compressing the blend into a tablet.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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