In another embodiment of system and method, by it is basic simultaneously or tissue sample and placement simultaneously multiple marker/reference nonlinears, distributed or three-dimensional configuration. The system and method can be applied to other forms and combine the combination that distributed/3 dimensions/spherical shape positioning may include a single process or method, this system may include 3D biopsies, origin reference location, brachyiherapy program requests, injection/infusion bioactive materials are (for example, chemotherapy, small molecule, porous material, cell, caustic, proteolysis, embolism materials, glue etc.), heat or conductance go out ablation.
