The system includes a biopsy needle assembly (100) for excising a tissuespecimen, andincludes a mandrel (102) with a core bed (116) forming a projection (122) formarking thespecimen. The projection can include a marking agent for marking the specimen.An actuatorassembly (200) used with needle assembly (100) includes a counter assembly(352)identifying the biopsy specimen during a procedure, and tracking thecumulative biopsiestaken with the actuator. A three-dimensional biopsy mapping and focal therapysystem (1102)uses an imaging system to generate and store a three-dimensional image (1472)of a targettissue. Biopsy site location and needle orientation are generated and storedwith the three-dimensionalimage. Lesion sites of the biopsied tissue specimens are recorded with thethree-dimensionalimage. Tumor volume is calculated and represented with the three-dimensionalimage. The three dimensional image is used to provide localized therapy to thediseased tissue.
