The dart delivery system is designed to be fired from a conventional shotgun. The dart body is enclosed within an outer casing of a shotgun shell. A needle with enclosed medication is connected to the dart body. A fragmentable tip is positioned at the end of the needle. In operation, when the shotgun shell is fired, the dart body and needle are propelled toward a target animal so that when the needle and fragmentable tip contact the skin of the animal, the tip fragments, the needle penetrates the skin, and the powdered, pelleted or lyophilized medication is expelled out the end of the needle and into the animal.