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RETINOID-CONTAINING PHARMACEUTICAL COMPOSITIONS FOR LOCAL APPLICATION OF TYPE OF “OIL IN WATER” EMULSION
专利权人:
ГАЛДЕРМА РЕСЕРЧ ЭНД ДЕВЕЛОПМЕНТ (FR)
发明人:
ДЮПРА Аньес (FR),МАЛЛАР Клер (FR)
申请号:
RU2014152992
公开号:
RU2014152992A
申请日:
2013.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical composition of the type of an oil-in-water emulsion comprising: an oil phase containing at least one active substance selected from retinoids, at least one basic solvent of the active substance, one or more oily auxiliary solvents and mineral oil; an aqueous phase containing at least one sucrose ester surfactant, at least one polyol and purified water. The composition according to claim 1, characterized in that the active substance is 3 ″ - tert-butyl-4 ′ - (2-hydroxyethoxy) -4 ″ - pyrrolidin-1-yl- [1,1 ′; 3 ′, 1 ′ ′] - terphenyl-4-carboxylic acid. 3. A composition according to claim 1, characterized in that the surfactant is selected from sucrose palmitate or sucrose stearate, or a mixture thereof. A composition according to claim 1, characterized in that the aqueous phase contains at least one gelling agent. A composition according to claim 4, characterized in that the gelling agent is a mixture of "sodium acryloyl dimethyl taurate / isohexadecane / polysorbate-80 copolymer." A composition according to claim 1, characterized in that the main solvent of the active substance is phenoxyethanol. A composition according to claim 1, characterized in that the oily auxiliary solvents are selected from triglycerides of caprylic / capric acid, almond oil, propylene glycol monocaprylate, propylene glycol laurate, sorbitan sesquioleate, PPG-15 stearyl ether, sorbitan sesquioleate, aberos ester oil 6 from P and. A composition according to claim 1, characterized in that the mineral oil is paraffin oil. The composition of claim 1, wherein the polyol is glycerol. 10. The composition according to p. 1, excellent1. Фармацевтическая композиция типа эмульсии "масло в воде", содержащая:- масляную фазу, содержащую по меньшей мере одно активное вещество, выбранное из ретиноидов, по меньшей мере один основной растворитель активного вещества, одно или несколько масляных вспомогательных растворителей и минеральное масло;- водную фазу, содержащую по меньшей мере одно пов
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