Novel pharmaceutical compositions of mometasone or a pharmaceuticallyacceptable derivate thereof in the formof an oil-in-water emulsion, notably a cream. The composition has excellentstability and therapeutic effect. The compositionscontain mometasone in micronised form, propylene glycol and water and theweight ratio between the propylene glycol and watercontained in the oil-in-water emulsion is from 1:1 to about 1:3.