A stationary trans-skull optogenetic stimulation module is provided and includes a sleeve configured to be inserted and positioned in a drilled hole of a skull, an optogenetic stimulating element, and a cover. The sleeve has a large aperture portion and a small aperture portion, and the optogenetic stimulating element and the cover can be installed with or disassembled from the large aperture portion. Thus, the operation time of syringe injection and phototherapeutic irradiation can be reduced, and the operation efficiency can be increased.一種頭骨固定式光刺激模組,包含一套筒、一光刺激元件及一蓋體,該套筒配置用以固定在一動物體之一頭骨之一鑽孔內,且具有一小孔徑部及一大孔徑部,該光刺激元件及該蓋體用以與該大孔徑部相組合。利用光刺激元件及蓋體可自該套筒上安裝及拆卸,而且能夠縮短針筒注射及光照射的作業時間,並提升作業效率。100‧‧‧頭骨固定式光刺激模組2‧‧‧套筒21‧‧‧小孔徑部22‧‧‧大孔徑部23‧‧‧內凸緣3‧‧‧光刺激元件31‧‧‧組合部32‧‧‧延伸部33‧‧‧通道34‧‧‧發光體35‧‧‧密封槽36‧‧‧導電端4‧‧‧蓋體41‧‧‧頂面42‧‧‧凹陷部5‧‧‧彈性環
