A stationary trans-skull optogenetic stimulation module is provided and includes a sleeve to be inserted and positioned in a drilled hole of a skull of a subject, an optogenetic stimulating element, and a cover. The sleeve has a large aperture portion and a small aperture portion, and the optogenetic stimulating element and the cover can be installed with or disassembled from the large aperture portion. Thus, the operation time of syringe injection and phototherapeutic irradiation can be reduced, and the operation efficiency can be increased.
