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METHOD FOR PREVENTING NEUROLOGICAL DISEASES
专利权人:
ИНТЕРНЭШНЛ СТЕМ СЕЛЛ КОРПОРЕЙШН (US)
发明人:
ГОНСАЛЕС Родольфо (US),ГАРИТАОНАНДИА Ибон (US),СЕМЕЧКИН Руслан (US)
申请号:
RU2014153894
公开号:
RU2014153894A
申请日:
2013.06.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for preventing or treating Parkinson's disease (PD), comprising administering to a subject in need thereof a therapeutically effective amount of at least one of guggulsterone, kinurenoy acid, or kenpaullon. A method according to claim 1, characterized in that guggulsterone is administered orally or by injection. A method according to claim 1, characterized in that guggulsterone is administered intravenously. A method for preventing the progression of PD, which comprises administering to a subject in need of a therapeutically effective amount of at least one of the following: guggulsterone, kinurenoy acid, or kenpaullon. 5. A method according to claim 4, characterized in that guggulsterone is administered orally or by injection. A method according to claim 4, characterized in that guggulsterone is administered intravenously. A method for modulating the activity of dopaminergic neurons in a subject in need thereof, which comprises contacting dopaminergic neurons with at least one of the following: guggulsterone, kinurenoy acid or kenpaullon, thereby modulating the activity of dopaminergic neurons. 8. A method according to claim 7, characterized in that the activity of dopaminergic neurons is stimulated or increased. A method according to claim 7, characterized in that the activity of dopaminergic neurons is the functioning of neurons, the survival of neurons, or the proliferation of axons. A method according to claim 7, characterized in that the release of dopamine is increased or stimulated. The method of claim 7, wherein the subject is suffering from a neurodegenerative disease or disorder. The method of claim 11, wherein the disease or disorder is1. Способ предупреждения или лечения болезни Паркинсона (БП), включающий введение субъекту, нуждающемуся в этом, терапевтически эффективного количества, по меньшей мере, одного из: гуггулстерона, кинуреновой кислоты или кенпауллона.2. Способ по п. 1, отличающийся тем, что гуггулстерон вводят перорально или с по
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