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CRISTAL DE N-[2-({2-[(2S)-2-CYANOPYRROLIDIN-1-YL]-2- OXOÉTHYL}AMINO)-2-MÉTHYLPROPYL]-2-MÉTHYLPYRAZOLO[1,5-a]PYRIMIDINE-6-CARBOXAMIDE
专利权人:
Sanwa Kagaku Kenkyusho Co.; Ltd
发明人:
申请号:
EP13834094.8
公开号:
EP2896623A1
申请日:
2013.08.27
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
An object is to provide a crystal of anagliptin, which has a high purity and is excellent in stability, low in hygroscopicity, and has a characteristic of easily dissolving into water, and a method for producing the crystal. An anagliptin crystal showing a powder X-ray diffraction pattern substantially the same as in Fig. 1, which has peaks around at 9.8°, 17.4°, 18.6°, 25.3°, and 25.8° as diffraction angles represented by 2θ. The crystal is obtained by reacting N-(2-amino-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide and (2S)-N-chloroacetyl-2-cyanopyrrolidine in an organic solvent, thereafter purifying the reaction solution by column chromatography to thus obtain an amorphia of anagliptin, and crystallizing the amorphia of anagliptin from 2-propanol.
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中国工程科技知识中心
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