Erik Nordling,Patrick Strömberg,Stefan Svensson Gelius
申请号：
US15764194
公开号：
US20180264089A1
申请日:
2016.09.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are a modified iduronate 2-sulfatase, a composition comprising a modified iduronate 2-sulfatase, as well as methods for preparing a modified iduronate 2-sulfatase and therapeutic use of such a iduronate 2-sulfatase. In particular, the present disclosure relates to a modified iduronate 2-sulfatase sulfatase comprising substantially no epitopes for glycan recognition receptors, wherein said iduronate 2-sulfatase has a catalytic activity of at least 50% of that of unmodified iduronate 2-sulfatase in vitro.
