NORDLING, ERIK,STROMBERG, PATRIK,SVENSSON GELIUS, STEFAN
申请号：
CA3000289
公开号：
CA3000289A1
申请日:
2016.09.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed herein are a modified lysosomal protein, methods for preparing a modified lysosomal protein and therapeutic use of such a modified protein. Further disclosed herein is a method of treating a mammal afflicted with a lysosomal storage disease.In particular, the present disclosure relates to a method of preparing a modified lysosomal protein, said method comprising reacting a glycosylated lysosomal protein with an alkali metal periodate and reacting said lysosomal protein with an alkali metal borohydride for a time period of no more than 2 h, thereby modifying glycan moieties of the lysosomal protein and reducing the activity of the lysosomal protein with respect to glycan recognition receptors.
