#$%^&*AU2013206248A120130704.pdf#####C:\mp a92f-da6a-4195-bb8f-led08a3d3864.DOC- 1/06/2013 ABSTRACT The present invention provides heterocyclicderivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.