#$%^&*AU2013200845B220150129.pdf#####C: N ortbl DCC DAR 492796II.DOC..13/02/2013 ABSTRACT The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.