A method and system are described for 3D digital endodontics characterized in that 3D imaging equipment such as a CT or MRI scanner, ultrasound or the like are used to digitize the infected tooth or teeth, a 3D representation of the root canal system is extracted from the image data and visualized on a computer screen, a surgical template is designed to guide the endodontic instruments to localize the root canal(s) intra-operatively and said guide is manufactured by means of a computer driven system (e.g. milling, rapid prototyping, etc.).