NO- AND H2S- RELEASING COMPOUNDS

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专利权人:

发明人:

申请号：

EP12824542.0

公开号：

EP2744487B1

申请日:

2012.08.15

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.

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