RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEWYORK
发明人:
KASHFI, KHOSROW,KODELA, RAVINDER
申请号：
EP12824542
公开号：
EP2744487A4
申请日:
2012.08.15
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
