ZHU, BING-YAN,SIU, MICHAEL,MAGNUSON, STEVEN R.,PASTOR, RICHARD,HAIYING, HE,YISONG, XIAO,JIFU, ZHENG,XING, XU,JUNPING, ZHAO,LYSSIKATOS, JOSEPH P.,HURLEY, CHRISTOPHER A.,LIU, WENDY,LIANG, JUN
申请号:
CA2727036
公开号:
CA2727036C
申请日:
2009.06.19
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
A compound of Formula (I), enantiomers, diasteriomers, tautomers orpharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinaseinhibitors. A pharmaceutical composition that includesa compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvantor vehicle, and methods of treating or lesseningthe severity of a disease or condition responsive to the inhibition of JAKkinase activity in a patient are disclosed. Formula (I).