Matthew David Butts,Robert Edgar Colborn,Peter John Bonitatibus, Jr.,Amit Mohan Kulkarni,Bruce Allan Hay,Andrew Soliz Torres,Brian Christopher Bales,Michael Ernest Marino
申请号：
US12344606
公开号：
US08728529B2
申请日:
2008.12.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
