COMBS, ANDREW P.,YUE, EDDY W.,SPARKS, RICHARD B.,ZHU, WENYU,ZHOU, JIACHENG,LIN, QIYAN,WENG, LINGKAI,YUE, TAI-YUEN,LIU, PINGLI
申请号：
CA2743975
公开号：
CA2743975C
申请日:
2009.07.07
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to 1,2,5-oxadiazolederivatives, and compositions of the same,which are inhibitors of indoleamine 2,3-dioxygenase andare useful in the treatment of cancer and other disorders,and to the processes and intermediates for making such1,2,5-oxadiazole derivatives. The present invention provides,inter alia, IDO inhibitors of Formula I: or a pharmaceuticallyacceptable salt thereof, wherein: R1 is NH2 orCH3； R2 is Cl, Br, CF3, CH3, or CN； R3 is H or F； and n is1 or 2.
