5-Alkyloxy-indolin-2-one derivatives (I) in the form of base, hydrates, solvates and/or cis/trans isomers are new. 5-Alkyloxy-indolin-2-one derivatives of formula (I) in the form of base, hydrates, solvates and/or cis/trans isomers are new. R 01-4C alkyl, mono- or polyfluoro 1-4C alkyl, -(CH 2) n-cyclopropyl, 2-4C alkenyl or 2-4C alkynyl, preferably methyl； R 1H, 1-4C alkyl, mono or polyfluoro-1-5C alkyl, hydroxy-1-5C alkyl or -(CH 2) m-3-5C cycloalkyl, 1-2C alkyl； Z 1H or halo, 1-4C alkyl, mono or polyfluoro-1-4C alkyl, 1-4C alkoxy, mono or polyfluoro-1-4C alkoxy or -(CH 2) n-cyclopropyl (optionally substituted by F), preferably halo and is present in position 2； Z 2T 1W 1, present in position 5； T 1-(CH 2) n-； W 1H, 1-4C alkyl, mono- or polyfluoro 1-4C alkyl or cyclopropyl (optionally substituted by F), -C(O)OR, -C(O)-NR 6R 7, -NR 8C(O)R 9, -NR 1 0R 1 1 or -OR 1 2, preferably -C(O)OR or -C(O)NR 6R 7； either R 6, R 7H, 1-6C alkyl or mono- or polyfluoro 1-6C alkyl, -(CH 2) m-3-6C cycloalkyl, -(CH 2) p-pyrrolidinyl, -(CH 2) p-piperidinyl, -(CH 2) p-pyridinyl (the pyrrolidinyl, piperidinyl and pyridinyl groups optionally substituted by halo, 1-4C alkyl, mono or polyfluoro 1-4C alkyl, benzyl or -OR), -(CH 2) q-NR 0 aR 0 b or -(CH 2) q-OR； or NR 6R 7monocyclic heterocycle (optionally substituted by F, 1-4C alkyl, mono- or polyfluoro 1-4C alkyl, -NR 0 1R or -OR), bicyclo heterocycle (optionally substituted by F, 1-4C alkyl, mono- or polyfluoro 1-4C alkyl, -OR or -N 0 1R)； R 8H, 1-4C alkyl or mono or polyfluoro-1-4C alkyl； R 9H, 1-4C alkyl, mono or polyfluoro 1-4C alkyl, -(CH 2) rNR 0 cR 0 d, -(CH 2) m-pyrrolidinyl, -(CH 2) m-piperidinyl, -(CH 2) m-pyridinyl (the pyrrolidinyl, piperidinyl or pyridinyl optionally substituted by 1-4C alkyl, halo, mono or polyfluoro-1-4C alkyl or benzyl)； R 1 0, R 1 1H, OH, 1-4C alkyl or mono or polyfluoro-1-4C alkyl； NR 1 0R 1 1monocyclic heterocycle (optionally substituted by 1-4C alkyl, mono or polyfluoro-1-4C alkyl or oxo)； R 1 21-4C alk
