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SUPSTITUIRANI 2-TIO-3,5-DICIJANO-4-FENIL-6-AMINOPIRIDINI I NJIHOVA UPOTREBA
专利权人:
BAYER PHARMA AG
发明人:
ROSENTRETER, ULRICH,KRAEMER, THOMAS,SHIMADA, MITSUYUKI,HUEBSCH, WALTER,DIEDRICHS, NICOLE,KRAHN, THOMAS,HENNINGER, KERSTIN,STASCH, JOHANNES-PETER,WISCHNAT, RALF
申请号:
HRP20040618
公开号:
HRP20040618B1
申请日:
2004.07.07
申请国别(地区):
HR
年份:
2013
代理人:
摘要:
2-Substituted methylthio-3,5-dicyanopyridine derivatives (I), their salts and/or hydrates and solvates are new. 2-Substituted methylthio-3,5-dicyanopyridine derivatives of formula (I), their salts and/or hydrates and solvates are new. n = 2-4; R<;1>; = H or 1-4C alkyl; and R<;2>; = pyridyl or thiazolyl optionally substituted by 1-4C alkyl, halo, amino dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, (thio)morpholinyl, piperidinyl, piperazinyl (optionally N-substituted by 1-4C alkyl), pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, thiazolyl (optionally substituted by 1-4C alkyl) or phenyl (optionally substituted by 1-3 of halo, 1-4C alkyl or alkoxy). An Independent claim is also included for a method for preparing (I) by reacting the corresponding 2-thiol with R<;2>;CH2X (III), where X = leaving group.Izum se odnosi na spojeve formule (I),na postupak za njihovu proizvodnju i na njihovu upotrebu kao selektivnih liganada koji se vežu na adenozin A1 receptore.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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