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Controlled release pharmaceutical compositions for acid labile drugs
专利权人:
SOLVAY PHARMACEUTICALS GMBH
发明人:
SHLIEOUT, GEORGE,KOELLN, CLAUS-JUERGEN,SCZESNY, FRITHJOF,ONKEN, JENS,KOERNER, ANDREAS
申请号:
NZ56596006
公开号:
NZ565960A
申请日:
2006.08.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is an enteric coating comprising a) at least one film-forming agent selected from the group consisting of cellulose acetate phthalate, hydroxypropyl methylcellulose acetate succinate, hydroxypropyl methylcellulose phthalate, methacrylic acid-ethyl methacrylate-copolymer, and mixtures of said film-forming agents; b) a plasticizer which is a mixture of cetyl alcohol and triethyl citrate; which are collectively present in an amount of greater than 3 percent by weight relative to the film forming agent and wherein the weight to weight ratio of cetyl alcohol to triethyl citrate is from 0.05: 1 to 1.1; and c) dimethicone as an anti-sticking agent in an amount of 1.5 to 3 percent by weight relative.
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