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1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER
专利权人:
ASTRAZENECA AB;CANCER RESEARCH TECHNOLOGY LIMITED
发明人:
CHARLES, Mark,FINLAY, Maurice,NISSINK, Johannes
申请号:
TN2018000127
公开号:
TN2018000127A1
申请日:
2016.11.30
申请国别(地区):
TN
年份:
2019
代理人:
摘要:
A compound of Formula (I) or a pharmaceutically acceptable sait thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R<;sup>;1<;/sup>; can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin- l-yl, 3-methoxyazetidin-l-yl, or 3,3- difluoroazetidin- l-yl; R<;sup>;2<;/sup>; can be hydrogen or fluoro; R<;sup>;3<;/sup>; can be hydrogen or methoxy; and R<;sup>;4<;/sup>; can be methoxy, ethoxy, or methoxymethyl; provided that when R<;sup>;1<;/sup>; is hydrogen, methoxy or trifluoromethoxy, then R<;sup>;3<;/sup>; is not hydrogen, and/or R<;sup>;4<;/sup>; is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS l.
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