FACTOR VIII-XTEN FUSIONS AND USES THEREOF

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专利权人:

发明人:

申请号：

EP14835828.6

公开号：

EP3033097A2

申请日:

2014.08.14

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.

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