Tongyao LIU,Pei-Yun CHANG,John KULMAN,Volker SCHELLENBERGER,Haiyan JIANG,Robert T. PETERS,Ekta Seth CHHABRA
申请号:
US14912047
公开号:
US20160199454A1
申请日:
2014.08.14
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.