PROBLEM TO BE SOLVED: To provide a highly-safe anti-inflammatory agent which is effective in the whole body even when being orally administered, and whose anti-inflammatory effect is so high as to be equal to that of an anti-inflammatory drug on the market, and to provide a method for producing the anti-inflammatory agent.SOLUTION: This anti-inflammatory agent includes as an active ingredient: a peptide to which a reducing sugar obtained by being treated by a protease by adding the reducing sugar to a protein is added, or an amino acid to which the reducing sugar is added； or a peptide obtained by treating a protein by a protease, or a peptide to which a reducing sugar obtained by adding the reducing sugar to an amino acid is added, or an amino acid to which the reducing sugar is added.【課題】 高い安全性を有し、かつ経口投与した場合でも全身において有効である上、その抗炎症効果は市販の抗炎症薬に匹敵するほど高い抗炎症剤およびその製造方法を提供する。【解決手段】 タンパク質に還元糖を付加させてタンパク質分解酵素で処理して得られる還元糖が付加されたペプチドや還元糖が付加されたアミノ酸、またはタンパク質をタンパク質分解酵素で処理して得られるペプチドやアミノ酸に還元糖を付加させた還元糖が付加されたペプチドや還元糖が付加されたアミノ酸を有効成分とする抗炎症剤。【選択図】 図８
