LIU SHI HUI,LEPPLA STEPHEN H,BUGGE THOMAS H,WEIN ALEXANDER N,PETERS DIANE E,LIU JIE,CHEN KUANG HUA
申请号：
IN201817007478
公开号：
IN201817007478A
申请日:
2018.02.28
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Disclosed is a Bacillus anthracis protective antigen (PA) comprising a PA amino acid sequence wherein one or more of amino acid residues I207 I210 E654 I656 R659 M662 Y681 and L687 as defined by reference to SEQ ID NO: 1 are independently substituted with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions nucleic acids recombinant expression vectors host cells populations of cells methods of treating or preventing cancer in a mammal and methods of inhibiting the growth of a target cell are also disclosed.
