STSNETWORKS;주식회사 에스티에스네트웍스; LTD.;NANORESOURCE CO.;NANORESOURCE CO., LTD.;나노리소스 주식회사
发明人:
KWON, Myoung Taek,권명택,RICCI, Jeremy,리치제레미,KIM, Sun Ok,김선옥,LIM, Sunhee,임선희,JI, Jeoungdae,지정대
申请号：
KRKR2016/004784
公开号：
WO2016/182277A2
申请日:
2016.05.09
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a method for delivering a bioactive substance into the skin by simultaneously attaching and solubilizing a hydrophilic bioactive substance and a hydrophobic bioactive substance on a surface of nanodiamond, followed by coating on a surface of the skin. The method of the present invention enables the solubilization of the hydrophobic bioactive substance and the loading of the hydrophobic bioactive substance together with the hydrophilic bioactive substance at the same time, so that the hydrophilic bioactive substance, which is difficult to penetrate into the skin stratum corneum, together with the hydrophobic substance, is delivered into the skin, thereby improving skin penetration. In the method of the present invention, the bioactive substance can be delivered into the skin without skin irritation or toxicity. In the method of the present invention, the skin penetration of the hydrophilic active substance, which is difficult to penetrate into the skin, can be improved by using a nanodiamond composite, and, at the same time, the nanodiamond per se remains on the surface of the skin to alleviate skin dryness through a moisturizing effect.La présente invention concerne un procédé pour administrer une substance bioactive dans la peau en fixant et en solubilisant simultanément une substance bioactive hydrophile et une substance bioactive hydrophobe sur une surface de nanodiamant, puis en en recouvrant une surface de la peau. Le procédé de la présente invention permet la solubilisation de la substance bioactive hydrophobe et le chargement de la substance bioactive hydrophobe avec la substance bioactive hydrophile en même temps, de sorte que la substance bioactive hydrophile, qu'il est difficile de faire pénétrer dans la couche cornée de la peau, conjointement à la substance hydrophobe, est administrée dans la peau, en améliorant ainsi sa pénétration de la peau. Dans le procédé de la présente invention, la substance bioactive peut être admi
