Фарбер, Борис Славинович,Фарбер, Софья Борисовна,Мартынов, Артур Викторович
申请号：
EA202090763
公开号：
EA202090763A1
申请日:
2017.11.15
申请国别(地区):
EA
年份:
2020
代理人:
摘要：
The invention relates to organic and bioorganic combinatorial chemistry and pharmacy, namely to a new combinatorial library of a dipyridamole derivative and supramolecular structures based on them, which, when used without separation into separate components, have high biological activity as a means of stimulating stem cell division in the form of pharmaceutical compositions in combination with inhibitors of phosphodiesterase and inhibitors of histone deacetylase and pharmaceutically acceptable excipients. Also, the composition can be used in the fight against resistant microorganisms by restoring their sensitivity to antibiotics. The proposed composition, including phosphodiesterase inhibitors and histone deacetylase inhibitors, as well as pharmaceutically acceptable excipients, additionally contains an undivided mixture of combinatorial dipyridamole derivatives obtained by simultaneous modification with at least two covalent modifying agents. Also, the following combinations can be used as covalent modifiers of dipyridamole: succinic anhydride and monochloroacetic acid； maleic anhydride and succinic anhydride； maleic anhydride and monochloroacetic acid or any two modifiers from the list: acetic anhydride, propionic anhydride, butanic anhydride, acetic-propionic anhydride, acetic-butanic anhydride, glutaric anhydride, phthalic anhydride, cis-aconitic anhydride isolimonic anhydride, acetyl chloride, acetyl fluoride, propionyl chloride, butyroyl chloride, ethoxyoxalyl monochloride. Also, the pharmaceutical composition may additionally contain ascorbic acid and bendazole.Изобретение относится к органической и биоорганической комбинаторной химии и фармации, а именно к новой комбинаторной библиотеке производного дипиридамола и супрамолекулярным структурам на их основе, которые при использовании без разделения на отдельные компоненты обладают высокой биологической активностью как средство стимуляции деления стволовых клеток в виде фармацевтических композиций в комбинации
