Macdonald, Lynn,Gurer, Cagan,Murphy, Andrew,Tu, Naxin,Voronina, Vera,Stevens, Sean
申请号：
NZ71713012
公开号：
NZ717130A
申请日:
2012.10.26
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Discloses an isolated non-human animal cell comprising at an endogenous Major Histocompatibility Complex II (MHC II) α gene locus a nucleotide sequence encoding a chimeric human/non-human MHC II α polypeptide, wherein a human portion of the chimeric human/non-human MHC II α polypeptide comprises a human MHC II α2 domain. Also disclosed is an isolated non-human animal cell comprising at an endogenous MHC II β gene locus a nucleotide sequence encoding a chimeric human/non-human MHC II β polypeptide, wherein a human portion of the chimeric human/non-human MHC II β polypeptide comprises a human MHC II β2 domain.
