1. The non-human animals kept on the endogenous gene locus α major histocompatibility complex II (MHC II) a nucleotide sequence encoding a chimeric human / non-human α polypeptide MHC II, and the human part of the chimeric human / non-human α polypeptide MHC II comprises the extracellular domain of the MHC II α human animal expresses functional iprichem MHC II cell surface zhivotnogo.2. Animal according to Claim. 1, in which the extracellular domain of human α MHC II contains domains α1 and a2 cheloveka.3. Animal according to Claim. 1, in which the nucleotide sequence is expressed under the regulatory control of the endogenous nonhuman α promoter and regulatory elements MHC II.4. Animal according to claim. 1, which does not relate to the person of the chimeric human / non-human α polypeptide MHC II contains the transmembrane and cytoplasmic domains of the endogenous non-human α polypeptide MHC II.5. Animal according to Claim. 1, in which part human chimeric human / non-human MHC II α polypeptide derived from a protein of human HLA class II, selected from the group consisting of HLA-DR, HLA-DQ and HLA-DP.6. An animal according to claim. 5, in which part human chimeric human / non-human MHC II α polypeptide derived from HLA-DR4 protein cheloveka.7. Animal according to Claim. 1, which represents gryzuna.8. An animal according to claim. 7, wherein the rodent is a mysh.9. Animal according to Claim. 1 further comprising an endogenous gene locus for MHC II β nucleotide sequence encoding a chimeric human /1. Не являющееся человеком животное, содержащее на эндогенном локусе гена α главного комплекса гистосовместимости II (МНС II) нуклеотидную последовательность, кодирующую химерный человеческий/не относящийся к человеку полипептид α МНС II,причем человеческая часть химерного человеческого/не относящегося к человеку полипептида α МНС II содержит внеклеточный домен α МНС II человека, ипричем животное экспрессирует функциональный комплекс МНС II на поверхности клетки животного.
