STEELE, ROBERT LEWIS,史提尔 罗伯特 路依斯,史提爾 羅伯特 路依斯,MUSSO, ANTHONY FEDELE,穆索 安东尼 费德尔,穆索 安東尼 費德爾,MUNDSCHENK, DAVID D.,穆申科 大卫D,穆申科 大衛D,VAN DE CASTEELE, RUSSELL,帆 德 卡斯提尔 罗素,帆 德 卡斯提爾 羅素
申请号：
TW104107502
公开号：
TW201622719A
申请日:
2015.03.09
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved Artemisinin Combination Therapy (ACT), known as ActRx Tri-ACT Plus. The improved ACT therapy includes administering a combination of four drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is administered to the individual. A fourth composition, an effective amount of primaquine, or its pharmaceutically acceptable derivatives or salts is administered to the individual.本發明描述一種治療罹患微生物感染,包括諸如瘧疾之寄生蟲疾病的個體之方法,其藉由使用改良之青蒿素組合療法(ACT),稱為ActRx Tri-ACT Plus。改良之ACT療法包括投予四種藥物之組合。在本發明之一個具體實例中,該方法包括向個體舌下投予包含治療有效量之蒿甲醚噴霧之第一組成物。隨後向該個體投予第二組成物,治療有效量之青蒿琥酯。向該個體投予第三組成物,有效量之小蘖鹼或其醫藥學上可接受之衍生物或鹽。向該個體投予第四組成物,有效量之伯胺喹或其醫藥學上可接受之衍生物或鹽。
