Andrew P. Isch;Patrick H. Ruane;Waleska Pérez-Segarra
发明人:
Andrew P. Isch,Patrick H. Ruane,Waleska Pérez-Segarra
申请号：
US13251821
公开号：
US20120027819A1
申请日:
2011.10.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
