The present invention relates to use of (thio)-carbamoyl-cyclohexane derivatives,particularly trans-4- {2-[4-(2,3 -dichlorophenyl)-piperazin-1-yl] -ethyl}-N,N- dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptablesalts thereof in the manufacture of a medicament for the treatment of schizophrenia.Furthermore, the present invention relates to the treatment of schizophreniathrough the administration of (thio)- carbamoyl cyclohexane derivatives,particularly trans-4- {2-[4-(2,3-dichlorophenyl)-piperazin- 1-yl] -ethyl}-N,N-dimethylcarbamoyl-cyclohexylamineand pharmaceutically acceptable salts thereof.