THE PRESENT INVENTION RELATES TO USE OF (THIO)-CARBAMOYL-CYCLOHEXANE DERIVATIVES, PARTICULARLY TRANS-4-{2-[4-(2,3-DICHLOROPHENYL)-PIPERAZIN-1-YL]-ETHYL}-N,N-DIMETHYLCARBAMOYL-CYCLOHEXYLAMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ACUTE MANIA. FURTHERMORE, THE PRESENT INVENTION RELATES TO THE TREATMENT OF ACUTE MANIA THROUGH THE ADMINISTRATION OF (THIO)-CARBAMOYL CYCLOHEXANE DERIVATIVES, PARTICULARLY TRANS-4-{2-[4-(2,3-DICHLOROPHENYL)-PIPERAZIN-1-YL]-ETHYL}-N,N-DIMETHYLCARBAMOYL-CYCLOHEXYLAMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.