Tamper resistant pharmaceutical composition and a process for the production of tamper resistant pharmaceutical composition are described herein. Tamper resistant pharmaceutical composition comprising drug substance and water soluble ingredient having cloud point greater than about 90° C., wherein the cloud point of the water soluble ingredient inhibit extraction of the drug substance from the pharmaceutical composition by hot water having temperature greater than about 90° C. Tamper resistant pharmaceutical composition comprising (a) drug substance； (b) water soluble ingredient； and (c) cloud point modifier, wherein the cloud point modifier increase the cloud point of the water soluble ingredient till at least about 90° C.； wherein the water soluble ingredient and the cloud point modifier inhibit extraction of the drug substance from the pharmaceutical composition by hot water having temperature greater than about 90° C. Tamper resistant pharmaceutical composition is prepared by thermal or non-thermal process.
