Mark Banaszak-Holl,Joseph Wallace,Blake Erickson,Clifford M. Les,Bradford G. Orr
申请号：
US12847408
公开号：
US08568692B2
申请日:
2010.07.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subjects bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subjects bone sample.
