Johannes Grillari,Elisabeth Schraml,Klaus Fortschegger,Regina Grillari
申请号：
US14094772
公开号：
US09150855B2
申请日:
2013.12.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to methods for diagnosing bone disorders and/or cardiovascular disorders in a subject, by contacting a biological sample from the subject with (a) a nucleic acid molecule which hybridizes to miR-31 or its 5 or 3′ isoforms or variants, or (b) an agent that binds to miR-31 or its 5′ or 3′ isoforms or variants； detecting and evaluating the hybridization signal of the nucleic acid molecule or agent with a polynucleotide or said miR-31 or its 5′ or 3′ isoforms or variants； and comparing the detected and evaluated hybridization or binding signal with that of a control sample, wherein a stronger hybridization signal or a stronger binding signal in the sample of the subject compared to that of the control sample is indicative for a risk of developing or having a bone disorder and/or cardiovascular disorder.
