Erik Keller;Karel Lavrijsen;Marina Cools;Maarten VAn Geffen;Ann Meulemans;Igor Alexnadrovich Mezine;Leen Thielemans
发明人:
Ann Meulemans,Karel Lavrijsen,Marina Cools,Erik Keller,Igor Alexnadrovich Mezine,Leen Thielemans,Maarten VAn Geffen
申请号：
US13497231
公开号：
US20120184537A1
申请日:
2010.09.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.
